AB1645 CONTRACEPTION IN WOMEN WITH IMMUNE-MEDIATED INFLAMMATORY DISEASE

Background Given that teratogenic medications prescribed to women with immune-mediated inflammatory disease (IMID) may cause significant fetal harm, the use of effective contraception is crucial in reproductive-age receiving potentially medications. Objectives To determine: Relationship between drugs and efficacy methods. The prevalence contraceptive methods reproductive age IMID. Methods Cross- sectional study (May 2021 - May 2022). All an IMID (rheumatology, dermatology gastroenterology external consultation) were invited participate. Patients rheumatoid arthritis, psoriatic ankylosing spondylitis, psoriasis, Crohn’s ulcerative colitis included. hysterectomy, primary or secondary amenorrhea excluded. A self-administered questionnaire including questions on was administered. Medications for identified assigned a pregnancy risk category (according FDA): Class B (safe during pregnancy), C (have not been adequately studied assign classification) D-X (potentially teratogenic, their relatively/ absolutely contraindicated pregnancy). For who multiple drugs, we FDA based drug highest potential teratogenicity. Contraceptive also classified according relative effectiveness (based World Health Organization (WHO)) (Table 1). When had more than one method most method. Our analysis categorizes as either A/B/C D/X, (“low risk” vs “high risk”). determine relationship used Chi-square tests. Results total 59 participated 2), mean 41.2 (SD ± 6.8) years. referred by 41 (69.5%) patients 1): 56.1% (23 patients) moderately effective, 31.7% (13) highly 9.8% (4) ineffective. Of drugs: 37.5% (15 did it considered has P value 0.668 3). Conclusion about 70%. In method, be ineffective least frequent. We found no teratogenicity References [1]Hunt N. Family Planning Rheumatoid Arthritis. Curr Rheumatol Rep. 2019;21:16 [2]Leverenz DL. Contraception arthritis arthritis. Clin Rheumatol. 2019;38:1207-12 Table 1. Frequency (N 41) Method (%) OMS classification Condoms 15 (36.6) Moderate Oral 7 (17.1) Surgical sterilization 6 (14.6) High Intrauterine device 4 (9.8) Coitus interruptus 3 (7.3) Ineffective Vasectomy 2 (4.9) Vaginal rings Emergency 1 (2.4) Subdermic implants 2. Diagnosis frequency 20 (34.9) Crohn ´s 12 (20.3) Psoriasis 11 (18.6) Ankylosing spondylitis 8 (13.6) Psoriatic (11.9) Ulcerative (1.7) 3. 40 ) 10 (25%) (37.5%) Low 19 (15.8%) 9 (47.4%) (36.8%) Acknowledgements: NIL. Disclosure Interests None Declared.